CPD Activities

Current knowledge on the highly leukotoxic JP2 clone of aa

Current knowledge on the highly leukotoxic JP2 clone of aa

Starting on :06:00 PM 17 April, 2015 Venue:Panafric
Ending on :08:00 PM 17 April, 2015 Max Credits:3.00
Moderator:Dr. Ober Jenipher Achieng' Activity Cost:500


1. Prof. Dorte Haubek
PhD, Dr.Odont, Department of Dentistry, Health, Aarhus University, Denmark.


Aggressive periodontitis is an inflammatory condition of the tooth-supporting tissues induced by microbial deposits. The aetiology of the disease is not fully understood. Recent findings suggest that the presence of a particular virulent type (called the JP2 genotype) of the oral bacterium Aggregatibacteractinomycetemcomitans is of importance in the aetiology of the disease. Mapping of the geographic occurrence of the JP2 genotype of A. actinomycetemcomitans, with an estimated origin some 2.400 years ago, has revealed that its colonization is largely restricted to individuals of African descent. Characteristic mutations allow JP2 clone isolates obtained from individuals from the Mediterranean region to be distinguished from isolates obtained from individuals originating from West Africa. These findings suggest that the JP2 clone initially emerged as a distinct genotype in the Mediterranean region of Africa and subsequently spread to West Africa, from where it might have been transferred to the American continent. The finding of a sustained selective colonization of individuals of African descent, despite geographical separation from the African continent for centuries, indicates that the JP2 clone might have a distinct host tropism. Epidemiological studies have shown that the JP2 clone of A. actinomycetemcomitans is a likely aetiological agent in the initiation of periodontal attachment loss in children and adolescents. Today, the JP2 clone can be found geographically widespread, including South and North America and Europe.


The presentation will give a brief update on the role of the dentist in the management of periodontal diseases in children and adolescents. Particular focus will be given to the more recent information on and the clinical relevance of the occurrence of a highly leukotoxic JP2 clone of A. actinomycetemcomitans in dental plaque in adolescent populations with a high prevalence of aggressive periodontitis. Thus, various ethnic aspects will be discussed

Online Register