CPD Activities

END TO END INFUSION SOLUTIONS


END TO END INFUSION SOLUTIONS


Starting on :06:00 PM 12 August, 2015 Venue:Boma Inn
Ending on :08:00 PM 19 August, 2015 Max Credits:5.00
Moderator:No Activity Moderator Activity Cost: Free Order

Presenters

1. Dr. Zipporah Gathuya
PAEDIATRIC ANAESTHESIOLOGIST
GETRUDES CHILDREN'S HOSPI

Description

A typical TCI system consists of three main components: a user interface incorporating a display and method to input data, microprocessors to run the pharmacokinetic modelling software and control the third component, namely the infusion device. 

 

Pharmacokinetic models attempt to describe the relationship between dose and plasma concentration with respect to time. A pharmacokinetic model is a mathematical model that can be used to predict the blood concentration profile of a drug after a bolus dose or after an infusion of varying duration. These models are typically derived from measuring arterial or venous plasma concentrations after a bolus or infusion in a group of volunteers, using standardised statistical approaches and computer software models.

 

Mathematical models generate some pharmacokinetic parameters such as volume of distribution and clearance. These can be used to calculate the loading dose and rate of infusion necessary to maintain a steady-state plasma concentration at equilibrium. Target concentrations are calculated, not measured


Objectives

A target controlled infusion (TCI) is an infusion controlled by a real time pharmacokinetic model that achieves a user defined blood or tissue concentration of a drug.





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